LSH project MOSAR (Mastering hOSpital Antimicrobial Resistance and its spread into the community). Infections caused by antimicrobial-resistant bacteria (AMRB) account for an increasing proportion of healthcare-associated infections, particularly in high-risk units such as intensive care units and surgery; patients discharged to rehabilitation units often remain carriers of AMRB, contributing to their dissemination into longer-term care areas and within the community. The overall objective of MOSAR is to gain breakthrough knowledge in the dynamics of transmission of AMRB, and address highly controversial issues by testing strategies to combat the emergence and spread of antimicrobial resistance, focusing on the major and emerging multi-drug antimicrobial resistant microorganisms in hospitals, now spreading into the community. Microbial genomics and human response to carriage of AMRB will be integrated with health sciences research, including interventionnal controlled studies in diverse hospital settings, mathematical modelling of resistance dynamics, and health economics. Results from MOSAR will inform healthcare workers and decision-makers on strategies for anticipating and mastering antimicrobial resistance. To achieve these objectives, MOSAR brings together internationally recognized experts in basic laboratory sciences, hospital epidemiology, clinical medicine, behavioural sciences, quantitative analysis and modelling, and health economics. MOSAR brings together 11 institutions recognized for their leadership in these areas, from 10 EU Member or Associated States, as well as 7 SMEs to develop and validate high-throughput automated molecular tools for detection of AMRB. A high level of co-ordination will be obtained through a professionally IT-supported and rigorous management structure, to achieve optimal synergy of the components of MOSAR. We aim to develop and validate rapid testing for AMRB and initiate the clinical trials during the first 18 months of the project, and then to build on the infrastructure to execute the joint research program.
- Eric Fleury, Mariano Beiro, Christophe Crespelle, Lucie Martinet (D-NET team, INRIA, IXXI, ENS Lyon)